Depression and its treatment

Depression and its treatment

Mood naturally fluctuates and everyone experiences highs and lows in their lives But in some cases changes in mood can become long-lasting Debilitating and can impair someone’s ability to hold down a job, or sustain meaningful relationships It’s estimated that around 10 percent of people will at some point in their lives suffer from depression a mood disorder characterized by several symptoms feeling sad Distressed Unmotivated Excessively tired And losing interest in once pleasurable activities known as anhedonia Many people with depression also suffer from anxiety Neuroimaging studies reveal that many brain circuits that normally regulate mood are dysregulated in depression Located deep within the brain the amygdala processes highly salient stimuli such as rewards and potential threats In depression the amygdala is overactive and responds excessively to negative events In turn the amygdala connects to a set of brain regions that hone the physiological and behavioral Response to emotional stimuli these areas include the medial prefrontal cortex the nucleus accumbens the hippocampus and the insula The hippocampus is involved in memory formation and along with the prefrontal cortex is particularly vulnerable to the effects of stress Depressed people are more susceptible to stress which can cause physical changes in the brain including atrophy of the hippocampus This and other changes in depressed people may cause inappropriate responses to emotional events The medial prefrontal cortex is involved in regulating how strongly we react to emotional stimuli Treatments such as antidepressant drugs cognitive behavioral therapy and electroconvulsive therapy affect the structure and function of these and other brain regions Animal models such as mice are critical in helping us understand the cellular and molecular changes underlying depression and develop better treatments Although it’s impossible to know if a mouse is depressed My subjected to chronic stress show some symptoms similar to depressed humans Such as anxiety like behavior less social interaction and a lack of interest in normally pleasurable activities While not all human depression is triggered by stress these models may still shed light on the biology of depression and they’re the closest scientists can get while studying mice as With humans chronic stress in mice can lead to atrophy of the hippocampus and prefrontal cortex Mouse studies have also shown altered neuronal plasticity in various brain regions including the hippocampus prefrontal cortex amygdala and nucleus accumbens In a healthy hippocampus Experiences can lead to changes in the connections between neurons resulting in learning these changes are referred to as plasticity chronic stress can reduce this plasticity Healthy brains also continue to produce new neurons in one part of the hippocampus These new neurons slowly mature and integrate into the circuitry where they have a strong effect on hippocampal activity and behavior These new neurons are also affected by stress. They reduced in number in stressed brains These effects may result from reduced levels of neurotrophins proteins that increase neuronal growth and plasticity Reduced plasticity may stop the hippocampus from being able to properly regulate the stress response Which may lead to a vicious cycle where stress perpetuates more stress The hippocampus is particularly affected But there can be reductions in plasticity elsewhere in the brain and together these changes could contribute to other symptoms of depression like an dona Whether these cellular changes seen in mice are involved in human depression remains unclear Most antidepressants available today rapidly increase the amount of the neurotransmitters serotonin and/or norepinephrine in the synapse However improvements in symptoms in patients and mice usually don’t occur until weeks after starting the treatment While the reasons for this delay aren’t fully understood Prolonged treatment with antidepressants can over time act to reverse some of the changes induced by chronic stress increasing neurotrophins expression and rebooting hippocampal plasticity Non-chemical treatments for depression including electroconvulsive shock also promote, hippocampal plasticity in mice Antidepressant treatment can also reverse stress induced changes in other areas of the brain including the prefrontal cortex and reward circuitry different treatments may target different regions to improve symptoms Recently the drug ketamine was found to have rapid antidepressant Effects in patients with depression as well as in rodent models with effects lasting for days the mechanism behind This is an area of active research Ketamine blocks a type of synaptic transmission Leading to activation of a number of signaling pathways an increasing neurotrophins expression these molecular changes result in increased plasticity in the prefrontal cortex and hippocampus and likely contribute to ketamine’s behavioural effects By studying the changes in the brain caused by chronic stress And how antidepressants like ketamine work to reverse them? Researchers may find new targets for treatment or new drugs that could act more quickly More specifically or more effectively than currently available treatments

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100 Replies to “Depression and its treatment”

  1. Nice video! Thank you for this information. Depression causes feelings of sadness and/or a loss of interest in activities once enjoyed. Fort Lauderdale Behavioral Wellness provides major depressive symptoms and treatments in Fort Lauderdale. The best way to deal with depression affecting you or your friends/family is to consult an expert.

  2. i was diagnosed wit schizophrenia. being depressed for a long time and now i experience tinitus and brain fog a lot

  3. RUNNING HELPS TAKEI NG LONG TERM ANTI Depression not knowing the real problem is risky i always had Depression never took pills only to find out IT WAS ADHD.

  4. Antidepressants probably cause more harm then they ever alleviate. That's why there is almost no published medical trials on them beyond 6 week trials. Psychopharmacology are the abusers, psychologists are the enablers.

  5. I was jobless at some point and cuz of that i was depressed. My Job provider said (at the time i was fighting not to go deep into depression), the guy said don't fight it, let depression take over. Stupidest idea he ever said. Little did the guy know, I got a job (decent one) months after. You can cure depression without drugs.

  6. "…to appoint unto them that mourn in Zion, to give unto them beauty for ashes, the oil of joy for mourning, the garment of praise for the spirit of heaviness; that they might be called trees of righteousness, the planting of the LORD, that he might be glorified."

    Spirit of Heaviness underlined.

    There are no known materialist solution to Depression for the cause is not material. It is the spirit of heaviness behind it.

    If your car is broken, you take your car to the repair shop, if you can afford it, you can take it straight to the maker which knows every bit of your car's part.

    God is the maker.

    Seek the help of the maker..

    Here is prayer link that can guide you through to get free from the torment of depression.

    For more, to understand the dark spirit in operation, why not check out this man's experience and learn what is going on.

  7. Nice video. One permanent cure for depression is meditation. Check out innerengineering meditation taught all over the world.

  8. I'm not sure when my depression started and I wonder if it started as far back as I can remember or some time in my childhood, or teen years – at the latest teen years I'm thinking. And throughout the years my depression I'm thinking has only worsened. Relocation disappointments and especially family of origin difficulties cause my depression to get much worse. Oh and also the bad, disrespectful treatment from people out in society worsened my depression – all this starting in grade school on up to college.

  9. keep yourself busy by increasing ur skills and try to talk with friends as much as u can. Try to be come sociable. Talking is really helpful.

  10. I hate this new me. I almost forgot how to be myself. I've been pretending to be myself although I know someone else has hijacked my brain.

  11. Meri tension ki means reason main 4 year village rahi aqal life mein matlab age 10 year pher city aa gi death two shadi per gi but two ghar ke elawa kahein bhi nahi meri behan cazn ek baji bushra ki funny batein aa ke batati abu kt death per gi death ke 2nd day sab women girls ko kaha rice saaf ker dein death walay ke name per degein pakani hai main baji bushra ki company mein bethi bychance afrad 5 tak ka group ho ga wo funny hansnay wali harkat batein ki main ne socha waqi funny hein batein funny kerti hein pher main 7 year baad village gi un ke ghar gi main baji bushra amnay samnay bethay thay baqi 7 afrad jo ek full group banta tha main ne socha ye abu ki death per funny batein ki thi jo sad time tha ab to milnay ye ab funny batein karein gi ek baat nahi ki main samjhy baji rabia dr us ke husband judge hein es liye tameez manners se bethi howi hein main ne poocha ap ki tabiat theek hai maiday ke elaaj ho raha tha bus two only khamoshi style se answer diye but wohi baji rabia abu ki death time to wahan majood thi mamlah kuch aur lagta hai pher main death per gi rabia kaam wali mili jin ka suna tha two ghar kaam kerti hein us ka face old age jurhyoun se bhara para tha weak alag but soochein only two kaam bones ko helah saktay hein mop poocha aur dustings .baton clothes jo washing machine sara kaam kerti hai roti to village mein ek look ki two women dekh ker eye onion type ki ho jati ziada kaam se but old aged skin impossible city jahan ye sara kaam hai ek woman nazer haisi nahi aye gi mujhay lagta hai old skin ki medicine se wo weak jurhriyan par rahi hein village mein impossibles but un ki sisters jin ke bachay ziada bhabies es ki khud ki beti sab normal but en ka hal zaberdasti kisi ne kia hai ye aj kal dekh rahi hn tension mein aa jati hn environment ke tore per ulat kaam ho rahay hein kaam ki waja se es ki skin onion jaisy hoti wo bhi bone ko harakat denay wala kaam poocha aur dusting hai only

  12. Sochti hn bahot but tession ziada nahi hai peace raheti hn main waisay jo kaam mein busy hn us mein magan ho jati hn ird gird environment ka na hosh raheta hai na dar lagta hai andehra matlab raat night environment sakoon feel ker rahi hoti hn loney hn darnay ke bajaye depress apnay past ki wajA se bahot ho jati hn

  13. Meri personal think ye hai politics mein all words ke saafeer safarat khana hein en ka basically matlab kia ye to tv jaisay external politician ka part day work per but es type ageny army ke speerah peer priest najoomi khenay matlab her ferqay ke peoples subcotinent many countries mein rahatay hein her muslim ghar mein islami only baby child paida nahi hota her colors ke jo chriastian israel hindu budha to rabb ne her insan ko control her field mein lanay ke liye army agency puray world ki her country mashati system chalanay ke liye becoz best work us color ka army agency le sakti hai na ke koi aur haisa samjhein jaisy iqwaimay muthedah tv media day ke tore per external dekhae jati hai haisay internal night time .night time tamam transport use ek kaam ke liye hoti hai night aeroplan se ayein khas area mein ab muslims mein unknown her girl ki shadi ho sakti hai army agency apnay color se jis ghar mein rishta kerwa dein girl ko khey dein apna religion na batana wo dar se ghar bachanay ki khayer agency ka her khena manein gi agency ko jo apnay color muslim ki zarorat howi politicaian army media labour khena ka matlab hight level per her country ek hein army agency base per safeer ki main work ye masherti all colors tamam country mein islam ki bina per ban nahi saktay na country ek country mein her color ki army agency us country mein rahay ker government ka saat deti hai soochein tamam saafer continue ek country mein kyoun atay hein

  14. Medicine jahan faiday hein wahan insan ko tang kernay ke liye bhi hein koi insan ko apnay saat na bethne dein aachar pickle kha letay hein jaan bojh ker flu ho jata hain pher jo nosi saaf kerta rahay bulgham shoper mein moth se koi us company beth saktay hein flu se koi marta to hai nahi koi daray .haisay koi split room ya waisay un ke saat bethna chayein ziada kha ker bed per continue beth ker gas kharij ki syrap ya phaki kha li mujhboran uthna para room se smell mein kon beth sakta hai ab batein gas kharij kernayvwali medicine patient ke liye hai normal insan ko tang kernay je liye bhi shitaani harbay unlimit hein

  15. Ab blood sara ramzan sharif se pehlay donate ke tore per de aye hard hot mein khud roza rakha na sab ke samnay acting se rakh lia ander se sab kuch khana halki yellow poder ya foundation base sab samjhein es ki shakal per rozay ka noor heaven jaisi yellow face kaam hot mein ful kerna dosray ne socha ye to mujh se ziada naik good habit ka malik hai rabb ne face per noor de dia hai mujh per to nahi kaam ziada ki waja se roza rakhna mushkel

  16. Kaam wali ka haisa haal hai malik nazer rakha howa hai itna ziada beautiful puri taqat zore se karien gay malik khey ga ye to meri soch se ziada honest kaam ker raha hai es base per trust ker ke next day ziada nazer na rakhay ga pher koi na dekhnay ki bina per jitnay kaam mein chore darwazay use ho saktay hein ker lein gay sari qaser nikal lena kaam ki pata kaisay chalta hai time her kaam apna time lazmi leta hai pura example main koi dish jitne fast banana chaoun cutting manage mein minute mein kaam ker loun but dish her 1hour half hour mein hi ban paye gi pehlay nahi haisay her kaam ke time jahan fast wahan koi chore rasta kharch kerna ye theek hai pak country mein jahan dust hi dyst ho ghar daily neat kerna taugh hai es liye dekh ker igbore ker jatay hein but chore rastay many

  17. Rabb ka karishma dekhein jahan en ko use kertay ajent kaam liye pher wahan un jism se kaam ker ke faida de ker aao pay es base per mil jati hai

  18. Ab humharay ghar ke samnay ghar hai us ghar ne apni reputation fazole kaam mein kharab ker ye batana cha ye bad akhlaq laalchi greedy hein saat meri sister bhai un ki bhar charh ker ghar mein batein kernay lagi main ne soocha humhara kia wasta her ek ka apna problem but mujhay ab pata chala mujhay tang kernay ke liye meri sister bhai fridge ke khanay ke bowl un ke ghar rakh dia ek din baad wapas ghar fridge mein main ne soocha kal tak tha nahi main socha yse ker gay but ye jaisay good fridge ziada cooling wala ho wahan ghar mein chupaya hota smell mere fridge se ziada cooling mujhay sari story bani banae samjh aa gi ghar abu behan zore zore se chekthay thay ye mouth ko helana na jaisay koi snaap dung maar gia ho neighbour per ghar mein sore special mere samnay barh charh ker baat be meaning fazole time waste demagh kharab kerna ab ye night time jab main so jati hn gi new new shitaani tareeqay seekh ker ana tang kerna mere saat problem ye hai meri soul per trick en ko bataye jatay hein meri solve mujh se easy solve ker wa deti hai meri soul na mili hoti main solve na ker pati training ke bagare .muharram haram mein shiya nation apnay app ko kyoun marti hai apnay heart chest breast ko reason enmy apni ander ki soul banti hai na ke koi aur

  19. Are you trying to sort things out for good,are you depressed,in pains or confused the good news is, a man who understand the things of life, who can read and study your life physically, spiritually,mentally and maritally creating a better future for you…his name is Dr MOLLA..he helped me during difficulties with my husband and today we are happy..I can recommend you to Dr MOLLA for your help too.([email protected])

  20. There is God's Way to stop depression and you will not be depressed again. Read this ebook – 'Depression Gone – God's Way". It is free in amazon.

  21. When are doctors finally going to stop treating symptoms and start to find te root causes of these illnesses?! Electrical shocks are you crazy?!!!!! Depression is caused by nutrient deficiencies and lack of good relationships. That’s what you need to work on in order to cure depression. People need friends. People need vitamin B3 and D3 and the amino acid tryptophane. And if your lactose intollerant you need lactic acid with it. This is how I cured my severe depressive dissorder. Not by listening to my psychiatrist wanting to give me medications.

  22. Glad they mentioned ketamine. Nothing else worked for me. Only change from 20 yrs of traditional treatment was an extreme decline in hormones. ( thyroid, testosterone, vitamin d levels, adrenals, along with CKD) And I eat a perfect diet. But from what I've read, Ketamine very little side effects & extremely high success rates. Hard part is to get a doctor & insurance to allow it.

  23. I'm depressed and suicidal from 11 years of old.
    I'm 26 now……
    severely bullied by my friend & family.
    I just hope one day I will die and end the pain.
    life is so beautiful but people living in this earth are ugly…

  24. كل اسباب الاكتأب
    العادة سرية خمول فكري اثار كارتية على دماغ خصوصا شباب في سن 20 23 30

  25. Whatever I don't Entertain Interference from in-laws. Ruined life of myDter. Whatever Happens Shall 🐻 with me Kahn Paheley K6un Baad Mean God us watching 📺 you.

  26. Practice makes a person perfect Positivity Can Lead to Peaceful Times Ahead. Smile is Free From. GrandMedical MotherCare solutions to get a simple solution for you guys have a nice time 👈

  27. आप में से किस किस को 5 साल से अधिक पुराना डिप्रेशन है अपना Whatsapp no. कमेंट में लिखे ताकि whatsapp group बना सके । अपना नाम , उम्र , रोग का नाम , राज्य , भाषा आदि 🔜🔜🔜

    कोई भी व्यक्ति विशेष जो मानसिक रोग का विशेषज्ञ हो इन whatsapp no. से whatsapp group तैयार कर सकता है ।

  28. Best treatment for depression is, do breathing exercises as prescribed in yoga ( Pranayama) and simple meditation with AH OOH MMMM sounds. You can see positive things happening.

  29. Start to accept sadness when it occurs and you will step by step understand how our nature works. It's a natural feeling. The thing is not to put layers after layers of different labels on that sad thought. Let go and just watch them, don't make them a part of you. Your thoughts are not some physical predators in real life, no one knows what you are thinking, you don't HAVE to do this and that, you WANT to do what ever you want. Sometimes it helps to just stop and really start to pull that real you forward and watch yourself like a movie.

  30. Cheers for this, I been tryin to find out about "what can i do to beat depression" for a while now, and I think this has helped. Have you ever come across – Hanincoln Nanlivia Framework – (just google it ) ? Ive heard some decent things about it and my co-worker got great results with it.

  31. I don't recommend taking antidepressant except if you want to take it for life because the withdrawal is worse than your depression

  32. My friend has a depression and she remains all the time dpressed ..i want to help her …but i can not find a way …can anyone give me any suggestions?

  33. i got depressed when i was a christian i thought God didn't love me anymore and jesus deserted me so i stopped being a christian and felt better now out of the clear blue i got depressed again, i've been fasting and eating just fruits i hope this helps also exercise!

  34. If depressed or anxious about anything and you are in UK then ring a free telephone number 116 123 anytime of day or night to talk to Samaritans

  35. Trevor and Steven, no understanding, no compassion. Aggressive, hostile behaviour. Disgusting and you getting paid to do this, to a severely ill person. You should hold your head in shame, God will judge you harshly, I say Father forgiven them, they do not know what they do. Don’t send them to hell.

  36. Something called Drugs. Not the bad drugs people talk about but Good drugs from you local clinic. Weed also helps depression (which is considered as bad drug unless given from your practitioner)

  37. "Electro-'convulsive' treatments"!!!! WHAAAAT?! Just pray to Jesus everyday to clean your heart, study bible daily to fill up on His word while your heart is being cleansed and the brain will naturally experience the same and follow through. The heart is sick, so the body is sick including the mind. I had depression for many years to the point where my brain suddenly and subtly told me to walk in front of a moving truck to kill myself. THIS is when my SPIRIT got a grip and went to war… I began crying out to Jesus daily in my prayers backed up by studying in His word to put on my armour so I could replace my feeble and corrupted mind with HIS all powerful one, my heart was changed in an instant when the Holy Spirit entered it felt like perfected peace & love, something I never felt before and literally saved my life! and I began to have visions. Yeah, I was sick for years detoxing of e-v-e-r-y-t-h-i-n-g after the fact, the body had to adapt (change) and I never looked back. Now I am ready for rapture, Praise the Lord! His love endures forever. Believe me, if you have the spiritual strength to live with depression, with G-ds help you certainly have the spiritual strength to come out of it.

  38. There is no treatment, postmortem studies on brains of people with mdd AND medicated, had serious impairments, just as they do when alive, and still take the pills, what that means obviously is that their pills do not work, what's more, meta analyses confirm both getting used to the drug this relapsing as well as the very same drugs causing even more severe depression both as stand alone And because the body becomes used to them. On top of these, and contrary to mainstream psychiatry, 4 neurotransmitters are targeted with antidep. While the brain has 60.and another 100lignsmts, neurosteroids, peptides, aas (that either directly or indirectly) modulate various physiological processes, so, in a brief, lose estimation there are over 2000to3000 combinations that really cause it, as such treatment should be double that because of the feedback and the complexity of brain. Currently no serious scientist admits that openly and obviously no one is pistulating that in the appropriate community etc either. Long story short, it's untreable contrary to what they will tell you, it also gonna take more than 200 years from now to have a better approach to all of that

  39. Excellent information !!! Good evening everyone.. this the disease is not doubt a chronic disorder and can have chronic can take ayurvedic treatment which will not cause any side effects and you can prefer Planet ayurveda's depression care pack.

  40. Where are the sources? And when providing information, I'd recommend giving an unbiased standpoint to both side. Antidepressants are just as effective as placebos. The cause to depression is unclear as now with only a few speculation. There are quite a few downsides to ketamine. Do your research more thoroughly and provide better sources.

  41. Vanilla extract, unpasteurized honey, and black pepper make a good synergy for an antidepressant. Look up HerbsPlusBeadWorks. And pray to God for your depression. It's not impossible. 🙂

  42. Almonds and wall nuts, only bon fire after Sun set not work. Wake up and see Sun rise. It works for me to get rid in 5 days, suffering from 3 months. thanks

  43. I have a twitter page with bible verses with those afflicted from mental illness. It is called Awake, Afflicted Jerusalem. I hope this helps.

  44. Rather than telling me how good healthy brains are how about telling me how to help my already not so healthy brain…Jesus Christ, every video, article, or person I talk to just talks about what a healthy brain does, how about providing hardcore solutions instead of general ideas. For fucks sake.

  45. ive been and tried multiple antidepressants and antipsychotics and there's been adverse effects so im now on benzodiazepines and doing ok mentally apart from the physical disabilities and pain that's been going in most of my life from accidents and multiple traumatic experiences since early childhood; its a very lonely life but il get by.

  46. What genius made this video impossible to watch by adding the horrible anxiety- and rage-inducing music? My guess is that most depressed people will be unable to concentrate on what the narrator is saying. I would be embarrassed to have my name associated with this video.

  47. Most serotonin is made in the gut. If you eat crap food, you will food crap.

    You wouldnt put crap fuel in your car and expect it to run well.

  48. And i take medication for depression psychosis and stress
    For the depression i take Espoza(escitalopram)10mg
    For stress i take Stedon(diazepam)10mg
    And for psychosis
    Etiapin(Quetiapin)100 200 and 300mg
    This is the best medication i evere had because is working fine on me..
    One espoza 10mg with one stedon 10mg and Etiapin 100 mg for the mornings then in afternoon i take one stedon10mg and etiapin 200mg
    And at the night 300 mg etiapin

  49. I was born happy and began living a life of depression form age 5 from suffering deadly child abuse up to age 16 when I finally fought back but life was still depressing from then in 1996 on my 16th to this day 2020 now it's a battle against the government and gangsters for survival for a share of life that you gotta steal, husi,l sell, pimp or even kill for But now that my faith grew in a word called God my stress levels have reduced dramatically even if I'm living still a HARD LIFE I can always depend on him God is good but pending on the volume of TRUST you put in him is what determines the amount of allowance as your personal provision to enable him working in you as he makes you not clever but bright! Like so Bright to see even in the darkest of this world how to jump hurdles and Qonquer mountains AMEN🙏💯❤Love is the Key and to share it to any one and everyone regardless if they take yet with patience you see it return in ways unimaginable ✝️🙏♎

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